LONGEVITY: EPIGENETIC AND BIOMOLECULAR ASPECTS

Longevity: epigenetic and biomolecular aspects

Many aging theories and their related molecular mechanisms have been proposed.Simple model organisms such as yeasts, worms, fruit flies and others Andirons have massively contributed to their clarification, and many genes and pathways have been associated with longevity regulation.Among them, insulin/IGF-1 plays a key and evolutionary conserved rol

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A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment

BACKGROUND: Therapeutic strategies targeting immune checkpoint proteins have led to significant responses in patients with various tumor types.The success of these studies has led to the development of various antibodies/inhibitors for the different checkpoint proteins involved in immune evasion of the tumor.Adenosine present in high concentrations

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Generalized lymphadenopathy: physical examination revisited

We report an unusual case of prostatic carcinoma in a 47-year-old male that presented with generalized lymphadenopathy.He initially presented with metastatic lymphadenopathy.He underwent a battery of investigations to find the primary site of origin but to Harz no avail.Thereafter, a complete and diligent physical examination revealed a hard and ir

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The Influence of Technological Conditions of the Process of Cogging in Flat Dies on the Quality of Two-Phase Titanium Alloys

To create a rational technology of cogging process and to determinate the optimal values of the angles of tilt and single reduction the stress-strain 8SB@PK state (SSS) of the blank during cogging in the flat dies was analyzed.By using the finite element method and program MSC.SuperForge quantitative data are obtained and Skin Serum the basic patte

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